Fundació Privada Institució Catalana de Recerca I Estudis Avançats;Fundació Privada Institut d'Investigació Oncològica de Vall-Hebron
发明人:
申请号：
EP15195339.5
公开号：
EP3048117A1
申请日:
2010.12.07
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
The present invention relates to a method of diagnosis and therapy of cancers expressing the HER2 receptor. In particular, it relates to an antibody or a fragment thereof that recognises an epitope of a HER2 receptor truncated form, said epitope being defined by a sequence included in SEQ ID NO: 2, wherein said antibody or fragment thereof is capable of discriminating between the truncated variant of HER2 CTF-611 represented by SEQ ID NO:1 and CTF-616 represented by SEQ ID NO:7, between the truncated variant of HER2 CTF-611 represented by SEQ ID NO:1 and the HER2 receptor and between the truncated variant of HER2 CTF-611 represented by SEQ ID NO:1 and the HER2 receptor truncated form 648-CTF/p95.
