PROBLEM TO BE SOLVED: To provide a medicine or food useful for the prevention or treatment of hypertriglyceridemia, fatty liver or diabetes.SOLUTION: This HNF (hepatocyte nuclear factor) -4&alpha activity inhibitor includes nitrogenistein as an active ingredient. The FXR (farnesoid X receptor) target gene expression modulator includes the nitrogenistein as the active ingredient.COPYRIGHT: (C)2008,JPO&INPIT【課題】高トリグリセリド血症、脂肪肝又は糖尿病の予防若しくは改善に有用な医薬又は食品の提供。【解決手段】ニトロゲニステインを有効成分とするHNF-4α活性抑制剤。【選択図】なし