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A 1,4,5-TRISUBSTITUTED1,2,3-TRIAZOLE MIMETIC OF RGD and/or OGP10-14, PROCESS TO OBTAIN IT AND USES THEREOF
专利权人:
发明人:
申请号:
EP12382535.8
公开号:
EP2749298A1
申请日:
2012.12.26
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
The present invention relates to nonpeptide compounds of formula (I) which are mimetics of RGD (Arg-Gly-Asp) and/or, OGP10-14 (Tyr-Gly-Phe-Gly-Gly), osteogenic peptides, containing a central 1,4,5-trisubstituted 1,2,3-triazole core and a reactive appendage appropriate to form covalent "click" bonds on the surface of materials functionalized with reactive groups including: azide, terminal alkyne, cyclooctalkyne, thiol, maleimide or thiolacid groups and to a process for the preparation of RGD and OGP10-14 mimetics containing a 1,4,5-trisubstituted 1,2,3-triazole core. These nonpeptide mimetics are particularly useful for medical devices, in particular implants and tissue engineering and cell culture matrices.
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