Prodrugs of phosphonate nucleotide analogs and methods for selecting and preparing them

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专利权人:

GILEAD SCIENCES; INC.

发明人:

Becker, Mark,Chapman, Harlan,Cihlar, Tomas,Eisenberg, Eugene,He, Gong-Xin,Kernan, Michael,Lee, William,Prisbe, Ernest,Rohloff, John,Sparacino, Mark

申请号：

ES13164300

公开号：

ES2627903T3

申请日:

2001.07.20

申请国别(地区):

ES

年份:

2017

代理人:

摘要：

A method for the manufacture of 9- [2- (phosphonomethoxy) propyl] adenine (PMPA) or 9- [2- (phosphonomethoxy) ethyl] adenine (PMEA) comprising reacting 9- (2-hydroxypropyl) adenine (HPA) or 9- (2-hydroxyethyl) adenine (HEA), magnesium alkoxide, and protected p-toluenesulfonoloxomethyl phosphonate.Un método para la fabricación de 9-[2-(fosfonometoxi)propil]adenina (PMPA) o 9-[2-(fosfonometoxi)etil] adenina (PMEA) que comprende hacer reaccionar 9-(2-hidroxipropil)adenina (HPA) o 9-(2-hidroxietil)adenina (HEA),, alcóxido de magnesio, y p-toluenosulfonoloxometilfosfonato protegido.

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