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Imidazoles and substituted fused pyrazoles and their uses
专利权人:
Bayer Intellectual Property GmbH;Bayer Pharma Aktiengesellschaft
发明人:
FOLLMANN, Markus,STASCH, Johannes-Peter,REDLICH, Gorden,GRIEBENOW, Nils,LANG, Dieter,WUNDER, Frank,PAULSEN, Holger,HÜBSCH, Walter,TERSTEEGEN, Adrian,VAKALOPOULOS, Alexandros
申请号:
ES13700985
公开号:
ES2654297T3
申请日:
2013.01.08
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
Compound of the formula I ** (See formula) ** in which A represents nitrogen or CR3 where R3 represents hydrogen, fluorine, difluoromethyl, trifluoromethyl, methyl, ethyl, cyclopropyl or cyclobutyl, L represents a group -CR4AR4B- (CR5AR5B) m-, where # represents the carbonyl group binding site, ## represents the pyrimidine or triazine ring binding site, m represents a number 0, R4A represents hydrogen, fluorine, methyl, ethyl, hydroxyl or amino, R4B represents hydrogen , fluorine, difluoromethyl, trifluoromethyl, methyl, ethyl, cyclopropyl, cyclobutyl, cyclopentyl or a group of the formula -M-R6, where methyl and ethyl can be substituted with 1 to 3 substituents independently selected from the group of fluorine, cyano, trifluoromethyl, cyclopropyl, cyclobutyl, difluoromethoxy and trifluoromethoxy, where R4B represents hydrogen, difluoromethyl, trifluoromethyl, methyl, ethyl, cyclopropyl, cyclobutyl, cyclopentyl or a group of the formula -M-R6, when R4A re It has hydroxyl, and where M represents a bond, R6 represents - (C>; = O) r-NR7R8, phenyl, thiazolyl, triazolyl, oxadiazolyl, thiadiazolyl or pyrimidinyl. ...Compuesto de la fórmula I **(Ver fórmula)** en la cual A representa nitrógeno o CR3 donde R3 representa hidrógeno, flúor, difluorometilo, trifluorometilo, metilo, etilo, ciclopropilo o ciclobutilo, L representa un grupo -CR4AR4B-(CR5AR5B)m- , donde # representa el sitio de unión al grupo carbonilo, ## representa el sitio de unión al anillo pirimidina o triazina, m representa un número 0, R4A representa hidrógeno, flúor, metilo, etilo, hidroxilo o amino, R4B representa hidrógeno, flúor, difluorometilo, trifluorometilo, metilo, etilo, ciclopropilo, ciclobutilo, ciclopentilo o un grupo de la fórmula -M-R6, donde metilo y etilo pueden estar sustituidos con 1 a 3 sustituyentes seleccionados independientemente del grupo de flúor, ciano, trifluorometilo, ciclopropilo, ciclobutilo, difluorometoxi y trifluorometoxi, donde R4B representa hidrógeno, difluorometilo, tri
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