The instant disclosure illustrates a method for manufacturing a hemostatic pharmaceutical composition including: dissolving human albumin molecular in a buffer solution for obtaining an albumin solution adding a surfactant, a crosslinking agent and a solvent to the albumin solution in a specific order for obtaining an albumin sphere suspension and adding fibrinogens to the albumin sphere suspension, wherein the fibrinogens are covalently bonded on the surface of the albumin spheres for forming double-layered protein spherical particles. The hemostatic pharmaceutical composition manufactured according to the instant disclosure is suitable for intravenous injection for treating patients with platelet deficiency.本發明揭示一種具有止血功能的醫藥組合物的製造方法,包括以下步驟:首先,將人體白蛋白分子溶於一緩衝液中,得到一白蛋白溶液;接著,在所述白蛋白溶液中依特定時序分別加入一表面活性劑、一交聯劑、及一溶劑,得到一白蛋白球體懸浮液;然後,在所述白蛋白球體懸浮液中加入纖維蛋白原,其中纖維蛋白原以共價鍵結合於白蛋白球體表面,形成雙層蛋白質球狀顆粒。利用本發明的製造方法所製成的醫藥組合物適於進行靜脈注射,以治療血小板缺乏的患者。步驟S100至步驟S106
