The present invention relates to a method and system for producing and delivering sterile, airless, and highly loaded ice slurry for inducing therapeutic hypothermia. The method is capable of producing and delivering ice slurry in a patient to induce hypothermia through internal and external cooling methods such as subcutaneous, intravascular, intraperitoneal, gastrointestinal, and lung methods. The method is capable of producing and delivering saline ice slurry or other phase-change slurries compatible with human tissues. Ice slurry is made by crushing, smoothing, and mixing ice slush in an airtight and self-collapsible liquid container, followed by being pumped out through flexible tubing and injection port into a patient body without air. The novel method and system are simple, and easy to use, which facilitate long term storage, immediately ready to use, and airless delivery.
