This invention relates to methods for administering an effective amount of a dietary or nutritional supplement composition that effectively changes the levels of biomarkers in the synovium of a joint and resulting in decreased pain and ultimately better outcomes for subjects. The formulation comprises an effective amount of the following: Boswellia； Vitamin C； Ginger； Turmeric； Vitamin D3； and Rutin. In a preferred embodiment of the composition of the invention, the composition is substantially free of omega-3 fatty acids.
