The invention relates to the use of a combination of cannabinoids for thetreatment of pain, inflammation and/or disease modification in arthritis.Preferably the cannabinoids are selected from cannabidiol (CBD) orcannabidivarin (CBDV) and delta-9-tetrahydrocannabinol (THC) ortetrahydrocannabinovarin (THCV). More preferably the cannabinoids are in apredefined ratio by weight of less than or equal to 19:1 of CBD or CBDV to THCor THCV.