Substituted aminobutyric derivatives as neprilysin inhibitors, their use, pharmaceutical composition, combination and method for inhibiting neutral endopeptidase activity.
Gary Mark Coppola,Gary Michael Ksander,Muneto Mogi,Rajeshri Ganesh Karki,Toshio Kawanami,Yuki Iwaki
申请号:
BRPI1015069
公开号:
BRPI1015069A2
申请日:
2010.05.26
申请国别(地区):
BR
年份:
2019
代理人:
摘要:
The present invention provides a compound of formula I'; or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.