Procédé pour la préparation et la purification du valgancyclovir

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专利权人:

FIDIA FARMACEUTICI S.P.A.

发明人:

申请号：

EP06012784.2

公开号：

EP1870411B1

申请日:

2006.06.21

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

A process for the preparation of valgancyclovir which comprises: a) reacting a compound of formula 7, in an aprotic solvent, in the presence of a condensing agent, with a compound of formula 8, wherein R 1 , and R 2 may be, each independently, hydrogen, an halogen atom or an hydroxyl group； the double bond may either be in the E or Z configuration or a mixture thereof to yield a compound of formula 9 b) mild hydrolysis of compound obtained in a) to give valgancyclovir.

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