The present invention provides an immunostimulatory complex specifically adapted to act as adjuvant and as a peptide immunogen stabilizer. The immunostimulatory complex comprises a CpG oligonucleotide and a biologically active peptide inmunogen. The immunostimulatory complex is particulate and can efficiently present peptide immunogens to the cells of the immune system to produce an immune response. The immunostimulatory complex may be formulated as a suspension for parenteral administration. The immunostimulatory complex may also be formulated in the form of w/o-emulsions, in combination with mineral salt suspensions orin-situ gelling polymers for the efficient delivery of immunogens to the cells of the immune system of a subject following parenteral administration, to produce an immune response which may also be a protective immune response.本發明係提供一種免疫刺激複合物，其特別適於作為一佐劑及一胜肽免疫原穩定劑。該免疫刺激複合物包含一CpG寡核苷酸及一具生物活性之胜肽免疫原。該免疫刺激複合物為顆粒狀且可有效遞送胜肽免疫原進入免疫系統細胞中，以產生免疫反應。該免疫刺激複合物亦可調配成懸浮液以利注射給藥。該免疫刺激複合物亦可調配成油包水乳液型式，如同一懸浮液與礦物鹽懸浮液之組合或與in-situ凝膠聚合物之組合，以有效利用注射給藥方式將免疫原傳遞至個體免疫系統之細胞中，以生成免疫反應，其係亦可為保護性免疫反應。
