University of Florida Research Foundation; Incorporated
发明人:
Li Zhong,Sergei Zolotukhin,Lakshmanan Govindasamy,Mavis Agbandje-McKenna,Arun Srivastava
申请号：
US15680668
公开号：
US20180036428A1
申请日:
2017.08.18
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Disclosed are tyrosine-modified rAAV vectors, as well as infectious virions, compositions, and pharmaceutical formulations that comprise them. Also disclosed are methods of preparing and methods for using the disclosed tyrosine-phosphorylated capsid protein mutant rAAV vectors in a variety of diagnostic and therapeutic applications including in vivo and ex vivo gene therapy, and large-scale production of rAAV vectors.
