LILIAN ALCARAZ,ANDREW P. CRIDLAND,CHRISTOPHER HURLEY,ANDREW S. JENNINGS
申请号：
ARP140102194
公开号：
AR096532A1
申请日:
2014.06.05
申请国别(地区):
AR
年份:
2016
代理人:
摘要：
Compounds and compositions that are MAPK p38 inhibitors, useful as anti-inflammatory agents in the treatment of, inter alia, respiratory tract diseases. Claim 1: A compound of the formula (1) or a pharmaceutically acceptable salt thereof characterized in that W is a heteroatom selected from N or O, wherein N is substituted with -H, C₁₋₆ alkyl or C₃₋₅ cycloalkyl； And it is selected from the group consisting of: a group -S (O) ₚ- where p is 0, 1 or 2； a group -O (CR³R⁴) ₙ-；a. One group - (cr8309；) (r8310)；1 group - No. 8311a；1 General Service (other level)One group - OC (o) NH -；And a group - OC (o) O -；R3,R830808,R⁵ and R⁶ are independently of each other -H, -F or C₁₋₆ alkyl, or, respectively, R³ and R⁴,or R⁵ and R⁶ may form together with the carbon atom to which a 3-6-membered saturated monocyclic carbocyclic ring is optionally substituted with a C₁₋₆ alkyl, hydroxyl or halo group； n is 0, 1, 2 or 3； R⁷ is -H, C₁₋₆ alkyl, or C₃₋₇ cycloalkyl wherein said C₁₋₆ alkyl or C₃₋₇ cycloalkyl is optionally substituted with a C₁₋₃ alkyl, C₃₋₆ cycloalkyl, hydroxyl, -CN or halo group； R¹ is a group selected from the compounds of formula (2) - (4)；R⁸ and R⁹ are independently of each other -H or C₁₋₆ alkyl, or R⁸ and R⁹ can form together with the nitrogen atom to which a fused monocyclic or bicyclic ring system or 4-11 membered saturated spiro are attached which optionally it contains an additional heteroatom that is oxygen or nitrogen, wherein said nitrogen atom is optionally substituted with C₁₋₆ alkyl； wherein said C₁₋₆ alkyl groups may be optionally substituted with a C₁₋₆ alkyl, C₃₋₆ cycloalkyl, hydroxyl or halo group； X¹,X2,X3,a. Carbon atoms, nitrogen atoms, a group - (CH) - or a group - (NH) are independent of each other；de manera que cada combinaci n de los mismos forma un sistema de anillos arom tico R se selecciona entre un grupo que consiste en -H -CN -NRARB -N (RC) (C alquilen) -NRARB -N (RC) (C cicloalquilen -N (RC) C (O) NRARB, -C (O) NRARB, -N (RC) C (O) N (RC) - (
