KANG, HEE CHOL,GEE, KYLE,MANDAVILLI, BHASKAR,YING, LAI-QIANG,BRANCHAUD, BRUCE
申请号：
EP11838687
公开号：
EP2635350A4
申请日:
2011.11.01
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
The present invention is directed to compounds, compositions, methods, and kits for detecting reactive oxygen species (ROS) by conventional fluorescence microscopy, fluorescence spectroscopy, flow cytometry, and/or high content imaging. The compounds disclosed herein are novel reduced dyes, including Cy-based hydrocyanine dyes and Cy-based deuterocyanine dyes, which dyes are probes for detecting ROS and measuring oxidative stress in cells either in vitro and/or in vivo. Also described herein are processes for preparing novel reduced dyes, i.e., ROS probes, for use in the disclosed compositions, methods and kits.
