LIU, SHU-HUI,HO, WEI-HSIEN,STROP, PAVEL,DORYWALSKA, MAGDALENA GRAZYNA,RAJPAL, ARVIND,SHELTON, DAVID LOUIS,TRAN, THOMAS-TOAN
申请号：
CA2954166
公开号：
CA2954166A1
申请日:
2012.11.07
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present invention provides antibodies that specifically bind totrophoblastcell-surface antigen-2 (Trop-2). The invention further provides antibodyconjugates comprising suchantibodies, antibody encoding nucleic acids, and methods of obtaining suchantibodies. Theinvention further relates to therapeutic methods for use of these antibodiesand Trop-2 antibodyconjugates for the treatment of a condition associated with Trop-2 expression(e.g., cancer), suchas colon, esophageal, gastric, head and neck, lung, ovarian, or pancreaticcancer.
