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ANTI-DENGUE VIRUS ANTIBODIES, POLYPEPTIDES CONTAINING VARIANT FC REGIONS, AND METHODS OF USE
专利权人:
Chugai Seiyaku Kabushiki Kaisha;Agency for Science, Technology and Research
发明人:
Zenjiro SAMPEI,Xing'er Christine KOO,Katja FINK,Roland ZUEST
申请号:
US16435979
公开号:
US20190315840A1
申请日:
2019.06.10
申请国别(地区):
US
年份:
2019
代理人:
摘要:
The disclosure provides anti-DENV antibodies and methods of making and using the same. Nucleic acids encoding anti-DENV antibodies and host cells comprising the nucleic acids are also provided. The anti-DENV antibodies have uses that include treating DENV infection. The disclosure also provided polypeptides containing a variant Fc region and methods of making the same. Nucleic acids encoding polypeptides and host cells comprising the nucleic acids are also provided. The polypeptides have uses that include treating a viral infection. Also claimed is a polypeptide comprising a Fc variant comprising at least one amino acid alteration in Sa parent Fc region, wherein the variant Fc region has a substantially decreased FcYR-binding activity and does not have a substantially decreased C1q-binding activity when compared to the parent Fc region.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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