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DEUTERATED BENZIMIDAZOLE COMPOUND AND MEDICAL USE THEREOF
专利权人:
Ltd.;Sumitomo Dainippon Pharma Co.
发明人:
Toshio Kanai,Kohei Iwamoto
申请号:
US16494128
公开号:
US20200017450A1
申请日:
2018.03.14
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The present invention relates to a medicament for treating or preventing a disease involving Na channel, for example, neuropathic pain, nociceptive pain, inflammatory pain, small-fiber neuropathy, erythromelalgia, paroxysmal extreme pain disorder, dysuria, or multiple sclerosis, comprising a compound of formula (I) wherein R1a, R1b, R1c, and R1d are hydrogen, halogen, cyano, C1-4 alkyl, C1-4 alkoxy, etc., provided that at least one of R1a, R1b, R1c and R1d is the above C6-10 aryl, C6-10 aryloxy, etc., R2 and R3 are hydrogen, C1-6 alkyl, C3-10 cycloalkyl, etc., R4 is hydrogen, C1-6 alkyl, C3-7 cycloalkyl, etc., m is 0, 1, or 2, L is CR7R8, R7 and R8 are hydrogen, hydroxy group, C1-4 alkyl, C1-4 alkoxy, etc., or a pharmaceutically acceptable salt thereof.
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