A bio-medical communication system includes a bio-medical unit and a communication device. The bio-medical unit is implantable in and/or affixable to a host body and includes a power harvesting module, a communication module, and a functional module. The communication device is operable to: set-up a communication with the bio-medical unit； wirelessly communicate the at least one of upstream data signal and downstream data signal with the bio-medical unit； convert the upstream data signal into an upstream wide area network (WAN) signal and/or a downstream WAN signal into the downstream data signal； and transmit or receive at least one of the upstream and downstream WAN signals.
