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UREA 2-CARBOXAMIDE CYCLOAMINO DERIVATIVES IN COMBINATION WITH HSP90 INHIBITORS FOR TREATMENT OF PROLIFERATIVE DISEASES
专利权人:
НОВАРТИС АГ (CH)
发明人:
ХУАН Сичжун (US),КВАДТ Корнелия (CH),ВАН Хой-Цинь (US),ФРИТЧ Кристин (CH),ШНЕЛЛЬ Кристиан Рене (CH)
申请号:
RU2014119339/15
公开号:
RU2014119339A
申请日:
2012.10.11
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A pharmaceutical combination comprising: (a) a compound of formula (I) (I), wherein A is heteroaryl selected from the group consisting of: R is one of the following substituents: (1) unsubstituted or substituted, preferably substituted CC-alkyl wherein said substituents are independently selected from one or more, preferably from one to nine of the following groups: deuterium, fluorine, or from one to two of the following CC-cycloalkyl groups; (2) optionally substituted C-C-cycloalkyl, wherein said substituents are independently selected from one or more, preferably one to four, of the following groups: deuterium, C-C-alkyl (preferably methyl), fluoro, cyano, aminocarbonyl; (3) optionally substituted phenyl, wherein said substituents are independently selected from one or more, preferably one to two, of the following groups: deuterium, halogen, cyano, CC-alkyl, CC-alkylamino, di (CC-alkyl) amino, CC- alkylaminocarbonyl, di (CC-alkyl) aminocarbonyl, CC-alkoxy; (4) an optionally mono- or di-substituted amine; where these substituents are independently selected from the following groups: deuterium, CC-alkyl (which is unsubstituted or substituted by one or more substituents selected from deuterium, fluorine, chlorine, hydroxy), phenylsulfonyl (which is unsubstituted or substituted by one or more, preferably one CC -alkyl, CC-alkoxy, di (CC-alkyl) amino-CC-alkoxy); (5) substituted sulfonyl; where the specified Deputy is selected from the following groups: C-C-alkyl (which is unsubstituted or substituted by one or more substituents selected from deuterium, fluorine), pyrrolidino (which is not1. Фармацевтическая комбинация, содержащая:(a) соединение формулы (I)(I),гдеA представляет собой гетероарил, выбранный из группы, состоящей из:Rпредставляет собой один из следующих заместителей: (1) незамещенный или замещенный, предпочтительно замещенный C-C-алкил, где указанные заместители независимо выбраны из одной или нескольких, предпочтительно от одной до девяти из следующих
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