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PIRROLIDINA-2-CARBOXAMIDAS SUSTITUIDAS
- 专利权人:
- F. HOFFMANN-LA ROCHE AG
- 发明人:
- BARTKOVITZ, DAVID JOSEPH,CHU, XIN-JIE,DING, QUINJIE,JIANG, NAN,LIU, JIN-JUN,ROSS, TINA MORGAN,ZHANG, JING,ZHANG, ZHUMING
- 申请号：
- PE0011842012
- 公开号：
- PE15322012A1
- 申请日:
- 2011.02.04
- 申请国别(地区):
- PE
- 年份:
- 2012
- 代理人:
- 摘要：
- Refers to a compound selected among: Tert Butyl ester acid [2 - (4 - [(2R, 3S, 4R, 5S) - 4 - (2 - Chloro - fluoro - phenyl) - 3 - (3 - Chloro - fluoro - phenyl - 2 - cyano - 4) 5 - (2,2-dimethyl - propyl) pyrrolidin-2-one carbonyl] amino} - phenyl) ethyl] - carbamic acid Chiral 1 - (4 - [(2R, 3S, 4R, 5S) - 4 - (2 - Chloro - fluoro - phenyl) - 3 (- 2 - 3 - Chloro - fluoro - phenyl) - 4 - (2 - cyano - 52 - dimethyl - propyl) pyrrolidin-2-one carbonyl] amino} - (piperidin-4-yl) phenyl carboxylic acid, 5 - [(2R, 3S, 4R, 5S) - 4 - (2 - Chloro - fluoro - phenyl) - 3 - (3 - Chloro - 2 - fluoro phenyl) - 5 - (4 - cyano - 2,2-dimethyl - propyl) pyrrolidin-2-one carbonyl] amino} - pirazin - 2 - carboxylic acid 4 - [(2R, 3S, 4R, 5S) - 4 - (2 - Chloro - fluoro - phenyl) - 3 - (3 - C Parrot - 2 - fluoro phenyl) - 4 - (2 - cyano - 52 - dimethyl - propyl) pyrrolidin-2-one carbonyl] amino} - 3 - methoxy benzoic acid, 4 - [(2R, 3S, 4R, 5S) - 4 - (2 - Chloro - fluoro - phenyl) - 3 - (3 - Chloro - fluoro - phenyl - 2) - 5 - (4 - cyano - 2,2-dimethyl - propyl) pyrrolidin-2-one carbonyl] amino} - 2 - trifluoromethyl benzoic acid among others. In addition to such a Pharmaceutical composition. This Compound is useful for the treatment of tumors of the breast, Colon, Lung and prostateSE REFIERE A UN COMPUESTO SELECCIONADO ENTRE: ESTER TERC-BUTILICO DEL ACIDO [2-(4-{[(2R,3S,4R,5S)-4-(4-CLORO-2-FLUORO-FENIL)-3-(3-CLORO-2-FLUORO-FENIL)-4-CIANO-5-(2,2-DIMETIL-PROPIL)-PIRROLIDIN-2-CARBONIL]-AMINO}-FENIL)-ETIL]-CARBAMICO QUIRAL ACIDO 1-(4-{[(2R,3S,4R,5S)-4-(4-CLORO-2-FLUORO-FENIL)-3-(3-CLORO-2-FLUORO-FENIL)-4-CIANO-5-(2,2-DIMETIL-PROPIL)-PIRROLIDIN-2-CARBONIL]-AMINO}-FENIL)-PIPERIDIN-4-CARBOXILICO ACIDO 5-{[(2R,3S,4R,5S)-4-(4-CLORO-2-FLUORO-FENIL)-3-(3-CLORO-2-FLUORO-FENIL)-4-CIANO-5-(2,2-DIMETIL-PROPIL)-PIRROLIDIN-2-CARBONIL]-AMINO}-PIRAZIN-2-CARBOXILICO ACIDO 4-{[(2R,3S,4R,5S)-4-(4-CLORO-2-FLUORO-FENIL)-3-(3-CLORO-2-FLUORO-FENIL)-4-CIANO-5-(2,2-DIMETIL-PROPIL)-PIRROLIDIN-2-CARBONIL]-AMINO}-3-M
- 来源网站：
- 中国工程科技知识中心
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- http://www.ckcest.cn/home/
