UNIVERSITY COLLEGE DUBLIN; NATIONAL UNIVERSITY OF IRELAND; DUBLIN
发明人:
Donal Mackernan,Shourjya Sanyal
申请号：
US15694592
公开号：
US20170370917A1
申请日:
2017.09.01
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The invention relates to a sensor molecule for detecting a target molecule comprising: (a) a rod-like molecule L and a rod-like molecule R connected to each other by a joint molecule C to form a hinge； (b) a target binding molecule A bonded to the end of rod-like molecule L opposite to the joint molecule C； (c) a binding molecule A′ bonded to the end of rod-like molecule R opposite the joint molecule C； wherein the target binding molecule A is arranged to bind to the target molecule to be detected, and binding molecule A′ is arranged to bind to: i) the same target molecule as target binding molecule A； or ii) a complex of the target binding molecule A and the target； and wherein the hinge is biased into an open position, such that target binding molecule A and binding molecule A′ are biased apart by the hinge.
