To provide orally rapidly disintegrating tablets containing bepotastine which is an active ingredient with bitter taste or a pharmacologically acceptable salt thereof, having an excellent oral disintegration and sufficient hardness at the same time, being capable of manufacturing at ordinary tablet production equipment, and the bitter taste being masked.SOLUTION: Provided are an orally rapidly disintegrating tablet containing bepotastine or a pharmacologically acceptable salt thereof, an additive, water-insoluble polymer, and a disintegrant； as well as a method for producing an orally rapidly disintegrating tablet comprising 1) mixing and granulating bepotastine and an additive to obtain granulated granules； 2) mixing additives with the granulated granules to obtain granules for tableting； and 3) compression molding of the granules for tableting； and a method comprising 1) mixing and granulating bepotastine or a pharmacologically acceptable salt excipient thereof to obtain granulated granules； 2) mixing the granulated granules and an additive to obtain tableting granules； and 3) compression molding the tableting granules.SELECTED DRAWING: None【課題】苦味を有する薬効成分であるベポタスチンまたはその薬理学的に許容しうる塩を含有する口腔内速崩壊性錠であって、苦味がマスキングされ、優れた口腔内崩壊性と充分な硬度を併せ持ちかつ、通常の錠剤製造設備で製造が可能な製剤の提供。【解決手段】ベポタスチンまたはその薬理学的に許容しうる塩；添加剤；水不溶性高分子；および崩壊剤を含有する、口腔内速崩壊性錠；ならびに口腔内速崩壊性錠の製造方法であって、１）ベポタスチンと添加剤を混合・造粒して造粒顆粒を得る工程；２）造粒顆粒と添加剤を混合して打錠用顆粒を得る工程；３）打錠用顆粒を圧縮成形する工程；を含む方法；および１）ベポタスチンまたはその薬理学的に許容しうる塩賦形剤を混合・造粒して造粒顆粒を得る工程；２）造粒顆粒および添加剤を混合して打錠用顆粒を得る工程；および３）当該打錠用顆粒を圧縮成形する工程；を含む方法。【選択図】なし
