AMBROSE, CATHERINE G.;CLYBURN, TERRY A.;MIKOS, ANTONIOS G.
发明人:
AMBROSE, CATHERINE G.,CLYBURN, TERRY A.,MIKOS, ANTONIOS G.
申请号：
AT03754460
公开号：
AT555748T
申请日:
2003.09.05
申请国别(地区):
AT
年份:
2012
代理人:
摘要：
Biodegradable microspheres implanted, injected, or otherwise placed totally or partially within the body are capable of near-linear controlled release of an antibiotic for a predetermined period of time for the treatment and prevention of infections involving the body. The microspheres are formed of polylactic-co-glycolic acid (PLGA) and an effective amount of antibiotic sufficient to produce bactericidal levels in body tissues, and may or may not include polyethylene glycol (PEG). The microspheres exhibit near-linear delivery of the antibiotic for at least 4 weeks at levels exceeding the minimum inhibitory concentration (MIC) for organisms commonly found to be the cause of infections.
