Eric Yi-Chun HUANG,Sze-Wah TSE,Jared IACOVELLI,Kristine MCKINNEY,Kristen HOPSON
申请号：
US15995519
公开号：
US20180311343A1
申请日:
2018.06.01
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The disclosure features isolated mRNAs encoding a polypeptide that enhances immune responses to an antigen(s) of interest, such as polypeptides that activate Type I interferon pathway signaling or NFkB signaling, including mRNAs comprising one or more modified nucleobase. The disclosure also features methods of using the same, for example, for enhancing immune responses when administered with an antigen(s) of interest, such as to stimulate anti-cancer immune responses or anti-pathogen immune responses.
