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Hydrolytically releasable prodrugs for sustained release nanoparticle formulations
专利权人:
Ivan Alferiev
发明人:
Ivan Alferiev,Michael Chorny,Robert J. Levy
申请号:
US13976776
公开号:
US09233163B2
申请日:
2011.12.28
申请国别(地区):
US
年份:
2016
代理人:
摘要:
A prodrug according to formula (I) wherein R2 is a residue of a drug, said drug having a hydroxyl group by which the COOR2 group is formed Z is O or NH m is 0 or 1 and R3 is an organic moiety comprising a lipophilic group or a residue of a polymer, provided that Z is 0 if the polymer is carboxymethyl dextran. A system includes a plurality of magnetic nanoparticles including a prodrug as described above, a stent and a source of uniform magnetic field capable of producing temporary magnetization of the stent and/or the magnetic nanoparticles. A method of treating a medical condition with a drug includes administering to a patient in need of the drug a prodrug as described above, the prodrug being capable of releasing the drug in the patient after the administration step.
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