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SUBSTITUTED OXADIAZOLE COMPOUNDS AND THEIR USE AS S1P1 AGONISTS
专利权人:
发明人:
DAS JAGABANDHU,KO SOO SUNG
申请号:
IN2167/CHENP/2013
公开号:
IN2013CN02167A
申请日:
2013.03.19
申请国别(地区):
IN
年份:
2016
代理人:
摘要:
Disclosed are compounds of Formula (I): [PLEASE INSERT CHEMICAL STRUCTURE HERE] or stereoisomers N oxides salts or prodrugs thereof wherein: Ring A is phenyl or 5 to 6 membered heteroaryl (i) R1 and R2 are independently C1 C4 alkyl or (ii) R1 and R2 together with the carbon atom to which they are attached form a cyclic group Q is phenyl or 5 to 6 membered heteroaryl substituted with zero to 3 substituents and R3 L1 L2 and n are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein coupled receptor S1P1 and pharmaceutical compositions comprising such compounds. These compounds are useful in treating preventing or slowing the progression of diseases or disorders in a variety of therapeutic areas such as autoimmune diseases and vascular disease.
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中国工程科技知识中心
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