CARBOXAMIDE-SUBSTITUTED PYRAZOLES AND TRI(HETERO)ARYL-PYRAZOLES FOR USE IN METHODS OF TREATING AND / OR PREVENTING CARDIOVASCULAR DISEASES AND / OR COMORBIDITIES THEREOF
The present invention relates to carboxamide-substituted pyrazoles and tri(hetero)aryl pyrazoles, pharmaceutical formulations containing such compounds, a process for manufacture and the use of such compounds in methods of reducing the heart rate and accordingly for its use in methods of treating and/or preventing cardiovascular diseases and/or cardiovascular comorbidities, which are exacerbated by an increased heart rate of ≥ 90 beats/min. (bpm), such as cardiac arrhythmia, hypertensive heart disease, tachycardia, inappropriate sinus tachycardia, angina pectoris and stable angina pectoris, myocardial ischemia, coronary artery disease, heart failure, and stroke, as well as the cardiovascular comorbidities diabetes, metabolic syndrome, obesity, and chronic kidney disease in mammals, including humans.