#$%^&*AU2011203031B220131212.pdf#####C :WRPonblDCC\AAR3712805_. UOC-22/U6/201 1 -25ABSTRACT This invention relates to methods for the detection of cardiovascular disease, e.g. acute coronary syndrome, heart failure and/or pulmonary embolism, in high body mass index 5 (BMI) individuals, e.g. with a BMI of 25-29, or 30 or above, and those with impaired renal function.