Refers to a compound of formula I, where RNA is an aza - heteroaryl c5-c6 r1 is H or F R2 is H or alkyl (c1-c4) R3 is h and R4A r4b are independently, h, F, CL, among others R5 is H, F, cl or Methyl R6 f is h, Methyl or Hydroxy is C - R7a, Z1 or Z2 is R7b N c - or N - R8 Z3 is c or N Z4 is R9 C - or N Z5 is C - R7a R10 or N and R7b are, independently, h, F, CL,Among others, R8 is H, F, cl or H is pentafluorosulfanilo Methyl R9, R10, among others is H, F, CL, among others. Preferred compounds are: N - {3 - cyano - 4 - methyl - 3 - [6 - (1,3 - thiazole - 5 - il) - 1H imidazole [1,2-b] pyrazol-1-yl] phenyl] - 5 - (pentafluoro -? 6 - sulfanyl) benzamide 3 - (2 - hidroxipropan - 2 - il) - N - (4 - methyl - 3 - [6 - (1,3 - thiazole - 5 - il) - 1H imidazo [1,2-b] pyrazol-1-yl] phenyl] - 5 - (pentafluoro -? 6 - sulfanyl) benzamide.It also relates to a Pharmaceutical composition. This Compound is useful in the treatment of angiogenic diseases.SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE ARN ES UN AZA-HETEROARILO C5-C6 R1 ES H O F R2 ES H O ALQUILO (C1-C4) R3 ES H R4A Y R4B SON INDEPENDIENTEMENTE ENTRE SI, H, F, CL, ENTRE OTROS R5 ES H, F, CL O METILO R6 ES H, F, METILO O HIDROXI, Z1 ES C-R7A O N Z2 ES C-R7B O N Z3 ES C-R8 O N Z4 ES C-R9 O N Z5 ES C-R10 O N R7A Y R7B SON, INDEPENDIENTEMENTE ENTRE SI, H, F, CL, ENTRE OTROS R8 ES H, F, CL O METILO R9 ES H, PENTAFLUOROSULFANILO, ENTRE OTROS R10 ES H, F, CL, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 3-CIANO-N-{4-METIL-3-[6-(1,3-TIAZOL-5-IL)-1H-IMIDAZOL[1,2-B]PIRAZOL-1-IL]FENIL}-5-(PENTAFLUORO- ?6-SULFANIL)BENZAMIDA 3-(2-HIDROXIPROPAN-2-IL)-N-{4-METIL-3-[6-(1,3-TIAZOL-5-IL)-1H-IMIDAZO[1,2-B]PIRAZOL-1-IL]FENIL}-5-(PENTAFLUORO- ?6-SULFANIL)BENZAMIDA. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES UTIL EN EL TRATAMIENTO DE ENFERMEDADES ANGIOGENICAS.
