Jennifer Leah Gori,Tongyao Wang,Hariharan Jayaram,Penrose ODonnell
申请号：
US15579633
公开号：
US20180296603A1
申请日:
2016.06.09
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Disclosed herein are compositions and methods for increasing the immunocompatibility of donor cells (e.g., HSCs or T-cells) for transplantation to a recipient subject, as well as database schemes for use in the methods. The methods and compositions described herein result in the allele-specific modification of one or more immunogenicity genes (e.g., an HLA gene) of a cell, resulting in cells that are suitable for transplantation into a recipient subject.
