Ligand binding molecules and uses thereof

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专利权人:

VEGENICS PTY LIMITED

发明人:

Gerometta, Michael,Adams, Timothy

申请号：

NZ71065814

公开号：

NZ710658A

申请日:

2014.02.13

申请国别(地区):

NZ

年份:

2019

代理人:

摘要：

The present invention is directed to ligand binding polypeptides which comprise a portion of VEGFR-3 extracellular domain and which bind to VEGF-C and VEGF-D, and uses thereof to modulate angiogenesis and/or lymphangiogenesis. A glycosylation sequon in the extracellular domain of wildtype VEGFR-3 has been modified to eliminate glycosylation at a specific site within the ligand binding polypeptides, providing improved pharmacological properties of the polypeptides, in particular when used as therapeutic proteins.

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