INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 March 2018 (01.03.2018) WIPO I PCT omit °nolo oui mom° oimIE (10) International Publication Number WO 2018/039612 Al (51) International Patent Classification: A61K 31/405 (2006.01) A61K 8/49 (2006.01) A61K 31/404 (2006.01) A61P 17/14 (2006.01) (21) International Application Number: PCT/US2017/048701 (22) International Filing Date: 25 August 2017 (25.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/380,205 26 August 2016 (26.08.2016) US 62/463,232 24 February 2017 (24.02.2017) US (71) Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]； 1111 Franklin Street, 12th Floor, Oakland, CA 94607-5200 (US). (72) Inventors: LOWRY, William, E.； University Of Califor- nia Los Angeles, Department Of Molecular Cell And De- velopmental Biology, 621 Charles Young Drive, Los An- geles, CA 90095 (US). CHRISTOFK, Heather； Univer- sity Of California Los Angeles, Department of Biological Chemistry, 615 Charles Young Drive South, Los Angeles, CA 90095 (US). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3)) W O 20 18/0396 12 Al (74) Agent: HALSTEAD, David, P. et al.； Foley Hoag Llp, 155 Seaport Boulevard, Boston, MA 02210-2600 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG,
