您的位置: 首页 > 农业专利 > 详情页

Imidazo[4,5-c]quinolines as DNA-PK inhibitors
专利权人:
Merck Patent GmbH
发明人:
Fuchss, Thomas,Mederski, Werner,Zenke, Frank
申请号:
AU2011298013
公开号:
AU2011298013B2
申请日:
2011.07.26
申请国别(地区):
AU
年份:
2015
代理人:
摘要:
The invention relates to compounds of the formulae (I) and (II) in which R1, R2, R3, R4, R5, R8, X and m are each as defined in the claims, and/or the physiologically acceptable salts, tautomers and stereoisomers thereof, including the mixtures thereof in all ratios. The compounds of the formula (I) can be used for inhibition of serine/threonine protein kinases and for sensitization of cancer cells to anticancer drugs and/or ionizing radiation. The invention also provides for the use of the compounds of the formula (I) in the prophylaxis, treatment or monitoring the course of cancer, tumors, metastases or angiogenetic disorders, in combination with radiotherapy and/or an anticancer drug. The invention further relates to a process for preparing the compounds of the formula (I) by reacting compounds of the formula (II) and optionally converting a base or acid of the compounds of the formula (I) to one of the salts thereof.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充