Wu, Herren,Young, James F.,Watkins, Jeffry D.,Johnson, Leslie S.,Koenig, Scott,Huse, William D.
申请号：
AU2012211451
公开号：
AU2012211451A1
申请日:
2012.08.09
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2012211451A120120830.pdf#####HIGH POTENCY RECOMBINANT ANTIBODIES AND METHOD FOR PRODUCING THEM Abstract High potency antibodies, including immunologically active fragments thereof, s having high kinetic association rate constants and optional high affinities are disclosed, along with methods for producing such antibodies. The high potency antibodies disclosed herein are of either the neutralizing or non-neutralizing type and have specificity for antigens displayed by microorganisms, especially viruses, as well as antigenic sites present on cancer cells and on various types of toxins, and the products of toxins. 1o Processes for production high potency neutralizing antibodies and increasing the potency of already existing neutralizing antibodies are also described. Methods of using said antibodies in the prevention and/or treatment of diseases, especially diseases induced or caused by viruses, are disclosed.
