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Inhibitors of Serine Proteases, Particularly HCV NS3-NS4A Protease
专利权人:
Incorporated;Vertex Pharmaceuticals
发明人:
Farmer, Luc J.,Perni, Robert B.,Bhisetti, Govinda Rao,Wilson, Keith P.
申请号:
AU2011203054
公开号:
AU2011203054B2
申请日:
2011.06.23
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
#$%^&*AU2011203054B220120426.pdf#####Abstract The present invention relates to compounds of formula (I) or a pharmaceutically acceptable salt, or mixtures thereof, that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are useful as antiviral agents. The invention further relates to pharmaceutically acceptable compositions comprising said compounds either for ex vivo use of for administration to a patient suffering from HCV infection and processes for preparing the compounds. The invention also relates to methods of treating HCV infection in a patient by administering a pharmaceutical composition comprising a compound of this invention. R1, V N W RR, 2 0 0
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