LANDGRAF, KYLE,STEIGER, DANIEL P.,WILLIAMS, STEVEN R.,MARTIN, DAVID W.,GEBHART, DANA,BARON, TARAH
申请号：
CA3027908
公开号：
CA3027908A1
申请日:
2016.06.24
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
This application relates generally to the production of polypeptides having specific antigen-binding properties of Fv domains, for example, insertable variable fragments of antibodies, and modified a1-a2 domains of NKG2D ligands. This application further relates to modified a1-a2 domains of NKG2D ligands attached to polypeptides, in some embodiments antibodies or fragments of antibodies. This application further relates to antigen-binding peptides derived from light and heavy chain antibody variable domains, which contain two linker regions and a split variable domain.
