The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid toxicity. More specifically the present invention relates to novel combinatorial therapies of Multiple Sclerosis Alzheimer s disease Alzheimer s disease related disorder Amyotrophic Lateral Sclerosis Parkinson s disease Huntington s disease neuropathic pain alcoholic neuropathy alcoholism or alcohol withdrawal or spinal cord injury based on Baclofen and Acamprosate combination.