The present invention relates to compositions and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid � toxicity. More specifically, the present invention relates to novel combinatorial therapies of Multiple Sclerosis, Alzheimers disease, Alzheimers disease related disorders, Amyotrophic Lateral Sclerosis, Parkinsons disease, Huntingtons disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury.