PROBLEM TO BE SOLVED: To provide a yohimbine derivative useful as an &alpha2 receptor blocker.SOLUTION: This new compound (salt thereof) is expressed by the formula (A) (wherein, R is H, an alkyl, alkenyl, aryl or the like). The other objective method for producing the above new compound is provided. A pharmaceutical composition containing the above new compound is also provided.COPYRIGHT: (C)2002,JPO【課題】 α2受容体遮断剤として有用なヨヒンビン誘導体の提供。【解決手段】 式(A):【化1】〔式中、Rは、水素、アルキル、アルケニル、アリール等を示す〕で表される化合物またはその塩、その製造方法およびそれを含有する医薬組成物。