МОНТЕЙТ Дэвид (US),О'Маллейн Джон (US),РЕО Джозеф П. (US),НЕЛЬСОН Деннис (US),ВАН Джианшень (US),ОМаллейн Джон (US)
申请号：
RU2010127737/15
公开号：
RU2010127737A
申请日:
2008.12.04
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. A pharmaceutical composition comprising phenylephrine or a pharmaceutically acceptable salt thereof, wherein the composition is formulated to be applied to the oral mucosa to provide improved systemic absorption of a therapeutically active form of phenylephrine. ! 2. The composition according to claim 1, where the composition is designed to provide immediate systemic absorption of a therapeutically active form of phenylephrine. ! 3. The composition according to claim 1, where the composition is designed to provide delayed systemic absorption of a therapeutically active form of phenylephrine. ! 4. A pharmaceutical composition suitable for sublingual systemic administration of phenylephrine or a pharmaceutically acceptable salt thereof, wherein the composition provides systemic absorption of phenylephrine from the bottom of the oral cavity. ! 5. The composition according to claim 4, where the composition is designed to provide immediate release of phenylephrine. ! 6. The composition according to claim 4, where the composition is designed to provide a delayed release of phenylephrine. ! 7. A pharmaceutical composition suitable for buccal systemic administration of phenylephrine or a pharmaceutically acceptable salt thereof, wherein the composition provides absorption of phenylephrine from the buccal mucosa. ! 8. The composition according to claim 7, where the composition is designed to provide immediate release of phenylephrine. !9. The composition of claim 7, wherein the composition is designed to provide a sustained release of phenylephrine. ! 10. The composition according to claim 1, where the composition provides the release of phenylephrine to provide a measurable plasma concentration of a therapeutically active form of phenylephrine in a subject for a period of at least four hours1. Фармацевтическая композиция, содержащая фенилэфрин или его фармацевтически приемлемую соль, где композиция создана для применения к слизистой оболочке ротовой полости, чтобы обеспе
