PIECZYKOLAN, JERZY SZCZEPAN,PAWLAK, SEBASTIAN,SZYMANIK, MICHAL,PIECZYKOLAN, ANNA MARIA,ZEREK, BARTLOMIEJ MACIEJ,ROZGA, PIOTR,JAWORSKI, ALBERT ROBERT,TESKA-KAMINSKA, MALGORZATA IZABELA
申请号：
PH12014501083
公开号：
PH12014501083A1
申请日:
2014.05.14
申请国别(地区):
PH
年份:
2014
代理人:
摘要：
A fusion protein comprising domain (a) which is a functional fragment of hTRAIL protein sequence, which fragment begins with an amino acid at a position not lower than hTRAIL95, or a homolog of said functional fragment having at least 70 pcnt sequence identity, preferably 85 pcnt identity and ending with the amino acid hTRAIL281 and domain (b) which is a sequence of an effector peptide inhibiting protein synthesis, wherein the sequence of domain (b) is attached at the C-terminus or N-terminus of domain (a). The fusion protein can be used for the treatment of cancer diseases.
