Pieczykolan, Jerzy Szczepan,Pawlak, Sebastian,Szymanik, Michal,Pieczykolan, Anna Maria,Zerek, Bartlomiej Maciej,Rozga, Piotr,Jaworski, Albert Robert,Teska-Kaminska, Malgorzata Izabela
申请号：
AU2012345494
公开号：
AU2012345494A1
申请日:
2012.11.28
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
A fusion protein comprising domain (a) which is a functional fragment of hTRAIL protein sequence, which fragment begins with an amino acid at a position not lower than hTRAIL95, or a homolog of said functional fragment having at least 70% sequence identity, preferably 85% identity and ending with the amino acid hTRAIL281； and domain (b) which is a sequence of an effector peptide inhibiting protein synthesis, wherein the sequence of domain (b) is attached at the C-terminus or N-terminus of domain (a). The fusion protein can be used for the treatment of cancer diseases.
