University of Louisville Research Foundation; Inc.
发明人:
MALDONADO, Claudio,MCCLAIN, Craig,BARVE, Shirish S.,GOBEJISHVILI, Leila,BAUER, Philip
申请号：
EP17870318
公开号：
EP3538076A4
申请日:
2017.11.08
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
Provided herein are compositions for treating liver inflammation. The compositions include a biologically active phosphodiesterase 4 (PDE4) inhibitor and a liposome, the liposome encapsulating the PDE4 inhibitor. The liposome may be anionic and include both neutrally charged and negatively charged phospholipids. Encapsulation of the PDE4 inhibitor in the liposome facilitates targeted delivery to the liver while limiting access to the central nervous system.
