Composition comprising a monoclonal antibody which specifically binds to human progastrin for use in the prevention or preventing recurrence or treating sensitive progastrin breast cancer, wherein said antibody comprises: * one chain variable region heavy in which CDR1 comprises the amino acid sequence of SEQ ID NO: 1, CDR2 comprising the amino acid sequence of SEQ ID NO: 2, and CDR3 comprising the amino acid sequence of SEQ ID NO: 3, and a variable light chain region wherein CDR1 comprises the amino acid sequence of SEQ ID NO: 4, CDR2 comprises the amino acid sequence of SEQ ID NO: 5 and CDR3 comprising the amino acid sequence of SEQ ID No: 6 or * a variable heavy chain region wherein CDR1 comprises the amino acid sequence of SEQ ID NO: 37, CDR2 comprising the amino acid sequence of SEQ ID NO: 41, and CDR3 comprising the amino acid sequence of No. SEQ ID: 45 and a variable light chain region wherein CDR1 comprises the amino acid sequence of SEQ ID NO: 49, CDR2 comprising the amino acid sequence of SEQ ID NO: 52, and CDR3 it comprises the amino acid sequence of SEQ ID NO: 55 or * a variable heavy chain region wherein CDR1 comprises the amino acid sequence of SEQ ID NO: 38, CDR2 comprising the amino acid sequence of SEQ ID NO: 42, and CDR3 comprising the amino acid sequence of No. SEQ ID: 46 and a variable light chain region wherein CDR1 comprises the amino acid sequence of SEQ ID NO: 50, CDR2 comprising the amino acid sequence of SEQ ID NO: 53, and CDR3 it comprises the amino acid sequence of SEQ ID NO: 56 or * a variable heavy chain region wherein CDR1 comprises the amino acid sequence of SEQ ID NO: 39, CDR2 comprising the amino acid sequence of SEQ ID NO: 43, and CDR3 comprising the amino acid sequence of No. SEQ ID: 47 and a variable light chain region wherein CDR1 comprises the amino acid sequence of SEQ ID NO: 50, CDR2 comprising the amino acid sequence of SEQ ID NO: 53, and CDR3 it comprises the amino acid sequence of SEQ ID NO: 57 or * a variable heavy chain
