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胃食道疾患を治療するための方法および組成物
专利权人:
ピーエッチ サイエンス ホールディングス,インコーポレーティド
发明人:
イズメール グロール,ロバート バーンズ,スティーブン ロイド
申请号:
JP2015532164
公开号:
JP6275725B2
申请日:
2013.09.18
申请国别(地区):
JP
年份:
2018
代理人:
摘要:
An orally administered composition that includes least one alkaline agent with a pH of at least 9.0 to 12.0, mixed in an aqueous vehicle with relatively high surface tension, high viscosity and lateral adhesion properties. When mixed, a low water soluble emulsion is formed that evenly coats and partially adheres to the lower section of the esophagus and the LES and forms a relatively long acting, protective barrier and partially neutralizes gastric acid. In one embodiment, the alkaline agent is potassium hydroxide and the aqueous vehicle is made of hydroxypropyl methyl cellulose, polyethylene glycol or ethylene glycol and additional thickener agents capable of withstanding high pH environments, such as xanthan gum, croscarmellose sodium, and microcrystalline cellulose. Additional organoleptic agents, such as gum Arabic and polyethylene glycol, flavorings, such as sodium chloride, acesulfame potassium, sodium saccharine, and mint, and stabilizers such as colloidal silica made be added.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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