HINZE, CLAUDIA, DR.,AULENBACHER, OTTO,SUNDERMANN, BERND, DR.,OBERBÖRSCH, STEFAN, DR.,FRIDERICHS, ELMAR, DR.,ENGLBERGER, WERNER, DR.,KÖGEL, BABETTE-YVONNE, DR.,LINZ, KLAUS, DR.,SCHICK, HANS, DR,SCHICK, HANS, DR.,SONNEN
申请号：
EP10005484.0
公开号：
EP2233487B1
申请日:
2003.11.05
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
Spiro-((4-amino-cyclohexane)-1,1'-1',3',4',9'-tetrahydropyrano-(3,4-b)-indole) derivatives (I) are new. Spiro-cyclic cyclohexylamine derivatives of formula (I), optionally in the form of racemates, pure stereoisomers (especially enantiomers or diastereomers) or their mixtures in all proportions, including free bases, free acids, salts (specifically acid or base addition salt) or solvates (specifically hydrates), are new. R1, R2 = H, optionally unsaturated, optionally mono- or polysubstituted 1-4C alkyl or CHO； R3 = -(CH2)n-Aryl； n = 0-2； R4 = H, optionally unsaturated, optionally mono- or polysubstituted 1-3C alkyl or -CO-(CH2)m-H； m = 0-2； R5 - R8 = H； 1-5C alkyl or 1-3C alkoxy (both optionally unsaturated and optionally mono- or polysubstituted)； or halo, OH, SH, SMe, OMe, NH2, COOH, COOMe, NHMe, NMe2 or NO2.
