IMPROVED PROCESS FOR PREPARATION OF METFORMIN HYDROCHLORIDE

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专利权人:

发明人:

KODURU RAMANARASIMHA MOORTHY,BHATTACHARYYA PABITRA KUMAR,KALE UDAY RAMCHANDRA,BHUWAN RANJAN

申请号：

IN1409/MUM/2010

公开号：

IN2010MU01409A

申请日:

2010.05.03

申请国别(地区):

IN

年份:

2012

代理人:

摘要：

Disclosed herein is a process for the preparation of high throughput crystalline metformin hydrochloride having uniform panicle size distribution and particle size reduction, with effective removal of impurity, DMA-HC1 using real-time INSITU GRINDING TECHNOLOGY during crystallization process from mother liquor. The current invention also discloses metformin oral solid dosage form with enhanced tablet strength, wherein, metformin is provided with better compact ability.

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