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Clusterin pharmaceuticals and treatment methods using the same
专利权人:
UNIVERSITY OF SOUTHERN CALIFORNIA
发明人:
M. Elizabeth Fini,Shinwu Jeong
申请号:
US14473622
公开号:
US09241974B2
申请日:
2014.08.29
申请国别(地区):
US
年份:
2016
代理人:
摘要:
Disclosed are pharmaceutical compositions comprising clusterin and polypeptides substantially the same as clusterin and treatment methods for inflammatory diseases and dry eye disease. The pharmaceutical compositions include an isolated clusterin or an isolated polypeptide substantially the same as clusterin. The clusterin is preferably secreted clusterin. The method of treating dry eye disease includes administering to a patient in need an effective amount of a pharmaceutical composition comprising an isolated clusterin or an isolated polypeptide substantially the same as clusterin. The method of treating a disease state characterized by inflammation includes administering to a patient having the disease state an amount of isolated clusterin or a protein substantially the same as clusterin effective to decrease the activity of a matrix metallproteinase selected from the group consisting of MMP-9, MMP-2 and MMP-7.
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