Provided are a fusion protein comprising the intermediate functional sequence (IFS) part of the FGFR Ig-like domain, FGFR second Ig-like domain (D2), FGFR third Ig-like domain (D3), and Immunoglobulin Fc region, nucleic acid molecule encoding the fusion protein, and the carrier and host cell comprising the nucleic acid molecule. Also provided are a preparation method for the fusion protein and the use of carriers or cells comprising the fusion protein, the nucleic acid molecule encoding the fusion protein, or the nucleic acid molecule in preparing medications for treating diseases related to angiogenesis regulation.
